CoreSolutions

This is your one-stop portal to the Core Facilities at Saint Louis University School of Medicine and our shared research resources. Our goal is to provide access to instruments, technologies, services, and expert consultation for our scientific and clinical investigators.

Biostatistics Core within the AHEAD Institute

The AHEAD Institute brings together SLU researchers from various fields and disciplines to help improve patient and population health, advance health care quality and decrease health care costs. The new institute will utilize and develop data resources; novel analytic methods; predictive modeling; machine learning; and integrated, wearable health devices and will collaborate with national research networks.

Animal Research Facility

The Animal Research Facility, located in the ABSL-3 facility of the vivarium in the Doisy Research Center, offers sophisticated equipment for the optical imaging of small animals.

Flow Cytometry Research Core Facility

In addition to five flow cytometers available, the Flow Cytometry Research Core Facility oversees multiple ancillary instruments for use with sample preparation or further analysis. A variety of software programs is also available for use in data analysis.

Genomics and Bioinformatics Core Facility

The Genomics Core Facility offers primarily single cell genomics and bioinformatics services to both internal and external users. The goal of the core is to make genomics-based projects easy and accessible to all labs, regardless of prior experience with genome wide research. 

Advanced Spatial Biology and Research Histology Facility

The Advanced Spatial Biology and Research Histology Facility provides a wide range of microscopy equipment and histological and microscopy services on a fee-for-service basis to researchers at Saint Louis University and other universities and businesses worldwide.

Light Electron Microscopy Laboratory

The Light Electron Microscopy Laboratory at Saint Louis University School of Medicine provides diagnostic electron microscopy (E.M.) services for a wide range of surgical specimens as stand-alone electron microscopic analysis or in conjunction with histological and immunohistochemical services provided by the Histopathology Laboratory.

Other Resources and Institutes

Institute for Drug Biotherapeutic Innovation

The I.D.B.I  A.D.M.E/P.K. Laboratoroy Service provides expertise, wet-bench support, L.C./M.S. analysis to help researchers determine pharmocokinetic (P.K.) parameters of potential therapeutics.  Drug absorption (A.), tissue distribution (D.), metabolism (M.), and excretion (E.) are critical parameters during drug development. 

Featured Publications

• Piening A, Ebert E, Gottlieb C, Khojandi N, Kuehm LM, Hoft SG, Pyles KD, McCommis KS, DiPaolo RJ, Ferris ST, Alspach E and Teague RM. Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk. (2024) Nat Commun.15, 2835
• Sur S, Bhartiya P, Steele R, Brennan M, DiPaolo RJ and Ray RB. Momordicine-I suppresses head and neck cancer growth by reprogrammimg immunosuppressive effect of the tumor-infiltrating macrophages and B lymphocytes. (2024) Mol Cancer Ther.
• Khojandi N, Connelly L, Piening A, Hoft SG, Pherson M, Donlin MJ, DiPaolo RJ and Teague RM. Single-cell analysis of peripheral CD8 T cell responses in patients receiving checkpoint blockade immunotherapy for cancer. (2023) Cancer Immunol Immunother. 72, 397-408
• Hoft SG, Pherson MD and DiPaolo RJ. Discovering Immune-Mediated Mechanisms of Gastric Carcinogenesis Through Single-Cell RNA Sequencing. (2022) Front Immunol. 13, 902017