Nicola Pozzi, Ph.D.

Professor
Biochemistry and Molecular Biology

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Research

Molecular mechanisms of thrombosis and immunothrombosis.

Research Interests

In our laboratory, we strive to understand the pathophysiological mechanisms that lead to thrombosis and immunothrombosis, an innate immune response that links coagulation to the recognition, containment and destruction of microbial pathogens. To achieve our goals, we apply a unique combination of biochemistry, protein engineering, X-ray crystallography, single molecule fluorescence biophysics (smFRET and FCS) and surface plasmon resonance (SPR).

Publications

Recent

Rational Design of Protein C Activators
Barranco-Medina S, Murphy M, Pelc L, Chen Z, Di Cera E and Pozzi N
Pubmed | Sci Rep

Molecular mapping of α-thrombin (αT)/β2-glycoprotein I (β2GpI) interaction reveals how β2GpI affects αT functions
Acquasaliente L, Peterle D, Tescari S, Pozzi N, Pengo V and De Filippis V
Pubmed | Biochem. J.

Costimulatory Effects of an Immunodominant Parasite Antigen Paradoxically Prevent Induction of Optimal CD8 T Cell Protective Immunity
Eickhoff CS, Zhang X, Vasconcelos JR, Motz RG, Sullivan NL, O’Shea K, Pozzi N, Gohara DW, Blase JR, Di Cera E and Hoft DF
Pubmed | PLoS Pathog.

Structural Architecture of Prothrombin in Solution Revealed by Single Molecule Spectroscopy
Pozzi N, Bystranowska D, Zuo X and Di Cera E
Pubmed | J. Biol. Chem.

Dual effect of histone H4 on prothrombin activation
Pozzi N and Di Cera E
Pubmed | J. Thromb. Haemost.